Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences.
نویسندگان
چکیده
We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of their (Py)U units.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 13 شماره
صفحات -
تاریخ انتشار 2014